Interferon-γ suppresses activin A/NF-E2 induction of erythroid gene expression through the NF-κB/c-Jun pathway.

@article{Lee2014InterferonSA,
  title={Interferon-γ suppresses activin A/NF-E2 induction of erythroid gene expression through the NF-κB/c-Jun pathway.},
  author={Williams v. Lee and Ming-Hui Chung and Yao Hung Tsai and Ju-Ling Chang and Huei-Mei Huang},
  journal={American journal of physiology. Cell physiology},
  year={2014},
  volume={306 4},
  pages={
          C407-14
        }
}
Interferon (IFN)-γ is a proinflammatory cytokine that is linked to erythropoiesis inhibition and may contribute to anemia. However, the mechanism of IFN-γ-inhibited erythropoiesis is unknown. Activin A, a member of the transforming growth factor (TGF)-β superfamily, induces the erythropoiesis of hematopoietic progenitor cells. In this study, a luciferase reporter assay showed that IFN-γ suppressed activin A-induced ζ-globin promoter activation in K562 erythroblast cells in a dose-dependent… CONTINUE READING

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Chronic IFNproduction in mice induces anemia by reducing erythrocyte life span and inhibiting erythropoiesis through an IRF-1/PU.1 axis

  • SF Libregts, L Gutiérrez, +6 authors MA. Nolte
  • Blood
  • 2011
2 Excerpts

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