Interferon-γ promoter is hypermethylated in blood DNA from workers with confirmed diisocyanate asthma.

@article{Ouyang2013InterferonPI,
  title={Interferon-γ promoter is hypermethylated in blood DNA from workers with confirmed diisocyanate asthma.},
  author={Bin Ouyang and David I. Bernstein and Zana L. Lummus and Jun Ying and L. -P. Boulet and A Pierre Cartier and Denyse Gautrin and Shuk-Mei Ho},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2013},
  volume={133 2},
  pages={218-24}
}
Risk factors have not been identified that determine susceptibility for development of diisocyanate-induced occupational asthma (DA). We hypothesized that diisocyanate (DI) exposure could modify gene promoter regions regulating transcription of cytokine mediators and thereby influence expression of DA. A cross-sectional study was designed to investigate the promoter methylation status of candidate genes in DI-exposed workers. Subjects consisted of 131 workers in three groups: 40 cases with DA… CONTINUE READING

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