Interferon-γ-induced necrosis: an antitumor biotherapeutic perspective.

Abstract

Interferon (IFN)-γ-like the well-known antitumor biotherapeutic IFN-α-is a powerful antiproliferative and immune modulatory cytokine, but mixed results from clinical trials, together with issues of systemic toxicity, have dampened enthusiasm for its use in the treatment of cancer. We suggest that at least 2 factors reduce the antitumor efficacy of IFN-γ: (1… (More)
DOI: 10.1089/jir.2012.0087

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