Interferon-γ Suppresses Intestinal Epithelial Aquaporin-1 Expression via Janus Kinase and STAT3 Activation

@inproceedings{Dicay2015InterferonSI,
  title={Interferon-γ Suppresses Intestinal Epithelial Aquaporin-1
Expression via Janus Kinase and STAT3 Activation},
  author={Michael S. Dicay and Christina L. Hirota and Natalie J. Ronaghan and Michael A. Peplowski and Raza S. Zaheer and Colin Carati and Wallace K MacNaughton},
  booktitle={PloS one},
  year={2015}
}
Inflammatory bowel diseases are associated with dysregulated electrolyte and water transport and resultant diarrhea. Aquaporins are transmembrane proteins that function as water channels in intestinal epithelial cells. We investigated the effect of the inflammatory cytokine, interferon-γ, which is a major player in inflammatory bowel diseases, on aquaporin-1 expression in a mouse colonic epithelial cell line, CMT93. CMT93 monolayers were exposed to 10 ng/mL interferon-γ and aquaporin-1 mRNA and… CONTINUE READING
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