Interferon-γ Alters Downstream Signaling Originating from Epidermal Growth Factor Receptor in Intestinal Epithelial Cells

@article{Paul2011InterferonAD,
  title={Interferon-γ Alters Downstream Signaling Originating from Epidermal Growth Factor Receptor in Intestinal Epithelial Cells},
  author={Gisela Paul and Ronald R. Marchelletta and Declan F McCole and Kim E Barrett},
  journal={The Journal of Biological Chemistry},
  year={2011},
  volume={287},
  pages={2144 - 2155}
}
  • Gisela Paul, Ronald R. Marchelletta, +1 author Kim E Barrett
  • Published 2011
  • Medicine, Biology
  • The Journal of Biological Chemistry
  • Background: Inflammation alters epithelial signaling. We studied how IFN-γ regulates EGFr signaling. Results: IFN-γ regulated EGFr expression, membrane localization, tyrosine residue phosphorylation, and linkage to MAPK. EGF no longer inhibited ion transport in IFN-γ-treated cells. Conclusion: EGFr signaling outcomes are altered by inflammation. Significance: These effects may contribute to diarrheal and other symptoms of inflammatory bowel diseases. The epidermal growth factor receptor (EGFr… CONTINUE READING

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    Modification of transepithelial ion transport in human cultured bronchial epithelial cells by interferon-gamma.