Interferon-γ, interleukins-6 and -4, and factor XIII-A as indirect markers of the classical and alternative macrophage activation pathways in chronic periodontitis.

@article{Navarrete2014InterferonIA,
  title={Interferon-γ, interleukins-6 and -4, and factor XIII-A as indirect markers of the classical and alternative macrophage activation pathways in chronic periodontitis.},
  author={Mariely Navarrete and Jocelyn Garc{\'i}a and Nicol{\'a}s Dutzan and Leslie Henr{\'i}quez and Javier Puente and Paola Carvajal and Marcela Hernandez and Jorge A Gamonal},
  journal={Journal of periodontology},
  year={2014},
  volume={85 5},
  pages={751-60}
}
BACKGROUND Macrophages account for 5% to 30% of the inflammatory infiltrate in periodontitis and are activated by the classic and alternative pathways. These pathways are identified by indirect markers, among which interferon (IFN)-γ and interleukin-6 (IL)-6 of the classic pathway and IL-4 of the alternative pathway have been studied widely. Recently, factor XIII-A (FXIII-A) was reported to be a good marker of alternative pathway activation. The aim of this study is to determine the macrophage… CONTINUE READING