Interferon-β gene transfer induces a strong cytotoxic bystander effect on melanoma cells.

Abstract

A local gene therapy scheme for the delivery of type I interferons could be an alternative for the treatment of melanoma. We evaluated the cytotoxic effects of interferon-β (IFNβ) gene lipofection on tumor cell lines derived from three human cutaneous and four canine mucosal melanomas. The cytotoxicity of human IFNβ gene lipofection resulted higher or… (More)
DOI: 10.1016/j.biopha.2015.04.002

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