Interferon-β directly influences monocyte infiltration into the central nervous system

  title={Interferon-β directly influences monocyte infiltration into the central nervous system},
  author={Sarah Floris and Sigrid R. Ruuls and Anne Wierinckx and Susanne M. A. van der Pol and Helga Eveline De Vries},
  journal={Journal of Neuroimmunology},
Interferon-h (IFN-h) has beneficial effects on the clinical symptoms of multiple sclerosis (MS) patients, but its exact mechanism of action is yet unknown. We here suggest that IFN-h directly modulates inflammatory events at the level of cerebral endothelium. IFN-h treatment resulted in a marked reduction of perivascular infiltrates in acute experimental allergic encephalomyelitis (EAE), the rat model for MS, which was coupled to a major decrease in the expression of the adhesion molecules ICAM… CONTINUE READING

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