Interferon-β-1 b decreased matrix metalloproteinase-9 serum levels in primary progressive multiple sclerosis


Recent reports have shown that matrix-metalloproteinases (MMPs) facilitate T-cell migration into the CNS and play a role in disruption of the blood-brain-barrier and myelin break-down. An increase of MMP-9 serum levels predicts disease activity in relapsing remitting multiple sclerosis (RRMS). Interferon-β (IFN-β), which is an established treatment for RRMS… (More)
DOI: 10.1007/s00415-003-0191-4


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