Interferon-α enhances antitumor activities of oncolytic adenovirus-mediated IL-24 expression in hepatocellular carcinoma

Abstract

Hepatocellular carcinoma (HCC) has a dismal 5-year-survival rate of 10%, so novel strategies are warranted. IL-24 mediates anti-tumor activity reducing STAT3 expression, which suggests that interferon (IFN) alpha may augment tumor cell lysis and reduce angiogenesis. We investigated the antitumor activity of treatment with IFN-α, with the oncolytic… (More)
DOI: 10.1186/1476-4598-11-31

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@inproceedings{Wang2011InterferonEA, title={Interferon-α enhances antitumor activities of oncolytic adenovirus-mediated IL-24 expression in hepatocellular carcinoma}, author={Cong-Jun Wang and Chao-Wen Xiao and T You and Ya-Xin Zheng and Wei Gao and Zhu-Qing Zhou and Jun Chen and Xin-bo Xue and Jia Fan and Hui Zhang}, booktitle={Molecular Cancer}, year={2011} }