Interferon-α-Induced Depression: When a Randomized Trial Is Not a Randomized Controlled Trial

@article{Ranjith2005InterferonInducedDW,
  title={Interferon-$\alpha$-Induced Depression: When a Randomized Trial Is Not a Randomized Controlled Trial},
  author={Gopinath Ranjith},
  journal={Psychotherapy and Psychosomatics},
  year={2005},
  volume={74},
  pages={387 - 387}
}
  • G. Ranjith
  • Published 1 October 2005
  • Medicine
  • Psychotherapy and Psychosomatics
Patten and Barbui [1] have performed a singular service to the profession by carrying out a systematic review on drug-induced depression. Their recommendations are based on studies that have randomly allocated patients into study and control groups, and the authors have provided an adequate justifi cation for this being the most scientifi c approach. This letter is to point out that the authors have erroneously designated a study as a randomized controlled trial. The authors state that… 

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Interferon Alpha-Induced Depression in Chronic Hepatitis C Patients: Comparison between Different Types of Interferon Alpha

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A very careful selection of hepatitis C patients is required before starting IFN alpha therapy, as leukocyte IFNAlpha seemed to present a more elevated tolerability than other IFNalpha types available for clinical practice.

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Evidence was found linking corticosteroids, interferon-α, interleukin-2, gonadotropin-releasing hormone agonists, mefloquine, progestin- releasing implanted contraceptives and propranolol to the etiology of atypical depressive syndromes.

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Recombinant preparations of the cytokine interferon (IFN)-α are increasingly used to treat a number of medical conditions, including chronic viral hepatitis and several malignancies, but although frequently effective, IFNαα induces a variety of neuropsychiatric adverse effects, including an acute confusional state, a depressive syndrome that develops more slowly over weeks to months of treatment, and manic conditions most often characterised by extreme irritability and agitation.

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