Interferon-, a Th 1 Cytokine , Regulates Fat Inflammation A Role for Adaptive Immunity in Obesity

@inproceedings{Rocha2008InterferonAT,
  title={Interferon-, a Th 1 Cytokine , Regulates Fat Inflammation A Role for Adaptive Immunity in Obesity},
  author={Viviane Zorzanelli Rocha and Eduardo J. Folco and Galina Sukhova and Koichi Shimizu and Israel Gotsman and Ashley Vernon and P. Scott Libby},
  year={2008}
}
Adipose tissue (AT) can accumulate macrophages and secrete several inflammatory mediators. Despite its pivotal role in the progression of chronic inflammatory processes such as atherosclerosis, the adaptive role of immunity in obesity remains poorly explored. Visceral AT of diet-induced obese C57BL/6 mice had higher numbers of both CD4 and CD8 T cells than lean controls, monitored by flow cytometry. When stimulated in vitro, T cells from obese AT produced more interferon (IFN) than those from… CONTINUE READING

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