Interferon (IFN)-gamma and Herpes simplex virus/tumor necrosis factor-alpha synergistically induce nitric oxide synthase 2 in macrophages through cooperative action of nuclear factor-kappa B and IFN regulatory factor-1.

@article{Paludan2001InterferonA,
  title={Interferon (IFN)-gamma and Herpes simplex virus/tumor necrosis factor-alpha synergistically induce nitric oxide synthase 2 in macrophages through cooperative action of nuclear factor-kappa B and IFN regulatory factor-1.},
  author={S\oren R Paludan and Lene Malmgaard and Svend Ellermann-Eriksen and Lisardo Bosc{\'a} and S\oren Chr Mogensen},
  journal={European cytokine network},
  year={2001},
  volume={12 2},
  pages={297-308}
}
The radical nitric oxide (NO) constitutes an important part of the innate immune response to many viruses, and among these notably Herpes simplex virus (HSV). We have previously shown that HSV/tumor necrosis factor-alpha (TNF-alpha) and IFN-gamma synergistically induce NO production in macrophages, and here we have investigated the molecular mechanism… CONTINUE READING