Interferon‐γ: an overview of signals, mechanisms and functions

@article{Schroder2004InterferonAO,
  title={Interferon‐$\gamma$: an overview of signals, mechanisms and functions},
  author={Kate Schroder and Paul J. Hertzog and Timothy Ravasi and David A. Hume},
  journal={Journal of Leukocyte Biology},
  year={2004},
  volume={75}
}
Interferon- (IFN-) coordinates a di- verse array of cellular programs through transcrip- tional regulation of immunologically relevant genes. [...] Key Result Cellular effects of IFN- are de- scribed, including up-regulation of pathogen rec- ognition, antigen processing, and presentation, the antiviral state, inhibition of cellular proliferation, and effects on apoptosis, activation of microbicidal effector functions, immunomodulation, and leuko- cyte trafficking. In addition, integration of signal- ing and…Expand
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Interferon‐γ (IFN‐γ) plays an important role in innate and adaptive immunity against intracellular infections and is used clinically for the prevention and control of infections in chronicExpand
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