Interfering with the connection between the nucleus and the cytoskeleton affects nuclear rotation, mechanotransduction and myogenesis.

@article{Brosig2010InterferingWT,
  title={Interfering with the connection between the nucleus and the cytoskeleton affects nuclear rotation, mechanotransduction and myogenesis.},
  author={Michaela Brosig and Jacqueline Ferralli and Laurent Gelman and Matthias Chiquet and Ruth Chiquet-Ehrismann},
  journal={The international journal of biochemistry & cell biology},
  year={2010},
  volume={42 10},
  pages={1717-28}
}
Mechanical stress controls a broad range of cellular functions. The cytoskeleton is physically connected to the extracellular matrix via integrin receptors, and to the nuclear lamina by the LINC complex that spans both nuclear membranes. We asked here how disruption of this direct link from the cytoskeleton to nuclear chromatin affects mechanotransduction. Fibroblasts grown on flexible silicone membranes reacted to cyclic stretch by nuclear rotation. This rotation was abolished by inhibition of… CONTINUE READING
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