Interfering with the Pathologic Activation of Microglial Cells and Astrocytes in Dementia

  title={Interfering with the Pathologic Activation of Microglial Cells and Astrocytes in Dementia},
  author={P. Schubert and K. Rudolphi},
  journal={Alzheimer Disease \& Associated Disorders},
Cascading glial cell activation is believed to play an essential pathogenic role in the development of dementia. Reactive microglia may contribute to neuronal damage by the generation of free oxygen radicals and nitric oxide (NO), which forms the particularly aggressive peroxynitrites, and by the release of potentially neurotoxic cytokines such as tumor necrosis factor-α (TNF-α). The pathologically stimulated release of interleukin-lβ (IL-lβ) from microglial cells triggers secondary activation… Expand
Turnover of oxidatively damaged nuclear proteins in BV‐2 microglial cells is linked to their activation state by poly(ADP‐ribose)polymerase
  • O. Ullrich, A. Diestel, +4 authors R. Nitsch
  • Biology, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2001
Neuroinflammation in Alzheimer's disease: chemokines produced by astrocytes and chemokine receptors.
Oxidative Stress and β-Amyloid Protein in Alzheimer’s Disease
CD38 regulation in activated astrocytes: Implications for neuroinflammation and HIV‐1 brain infection