Interfering with the Pathologic Activation of Microglial Cells and Astrocytes in Dementia

@article{Schubert1998InterferingWT,
  title={Interfering with the Pathologic Activation of Microglial Cells and Astrocytes in Dementia},
  author={P. Schubert and K. Rudolphi},
  journal={Alzheimer Disease \& Associated Disorders},
  year={1998},
  volume={12},
  pages={S29}
}
Cascading glial cell activation is believed to play an essential pathogenic role in the development of dementia. Reactive microglia may contribute to neuronal damage by the generation of free oxygen radicals and nitric oxide (NO), which forms the particularly aggressive peroxynitrites, and by the release of potentially neurotoxic cytokines such as tumor necrosis factor-α (TNF-α). The pathologically stimulated release of interleukin-lβ (IL-lβ) from microglial cells triggers secondary activation… Expand
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