Interfering with baffled B cells at the lupus tollway: Promises, successes, and failed expectations.

@article{Singh2016InterferingWB,
  title={Interfering with baffled B cells at the lupus tollway: Promises, successes, and failed expectations.},
  author={Namrata Singh and Bharat Kumar and Vijay Aluri and Petar S. Lenert},
  journal={The Journal of allergy and clinical immunology},
  year={2016},
  volume={137 5},
  pages={
          1325-33
        }
}
B cells play an important role in systemic lupus erythematosus by acting not only as precursors of autoantibody-producing cells but also as antigen-presenting, cytokine-secreting, and regulatory cells. Unopposed activation of B cells through their B-cell receptor for antigen, as seen in B cells lacking Lyn kinase, results in systemic autoimmunity. The B-cell activating factor of the TNF family (BAFF), nucleic acid-sensing Toll-like receptors (TLRs), and type I interferon can affect B-cell… CONTINUE READING
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CD19: a promising B cell target for rheumatoid arthritis

Nature Reviews Rheumatology • 2009
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