Interfering with Theories of Sleep and Memory: Sleep, Declarative Memory, and Associative Interference

  title={Interfering with Theories of Sleep and Memory: Sleep, Declarative Memory, and Associative Interference},
  author={Jeffrey M. Ellenbogen and Justin C. Hulbert and Robert Stickgold and David F. Dinges and Sharon L. Thompson-Schill},
  journal={Current Biology},

Figures and Tables from this paper

The contribution of sleep to hippocampus-dependent memory consolidation
Sleep selectively enhances hippocampus-dependent memory in mice.
Findings provide direct evidence of a role for sleep in enhancing hippocampus-dependent memory consolidation in rodents and detail a novel paradigm for examining sleep-induced memory effects.
The Sleeping Brain's Influence on Verbal Memory: Boosting Resistance to Interference
By introducing interference after sleep, this study confirms an experimental paradigm that demonstrates the active role of sleep in consolidating memory, and unmasks the large magnitude of that benefit.
A deficit in the ability to form new human memories without sleep
It appears that sleep before learning is critical in preparing the human brain for next-day memory formation—a worrying finding considering society's increasing erosion of sleep time.
Sleep-Dependent Facilitation of Episodic Memory Details
It is suggested that sleep may preferentially benefit contextual aspects of memory, supported by sleep-spindle oscillations, and that the temporal order of initial learning differentially determines subsequent offline consolidation.
Sleep and Memory Consolidation
The reviewed work provides a clear picture of the function of sleep on memory consolidation and presents critical questions that will be essential to address regarding the extent of and limitations on sleep-dependent memory consolidation.
Evidence for sleep-dependent memory consolidation in humans and mice
A naturalistic method to examine whether Pavlovian fear conditioning is enhanced after a sleep phase, as compared with an equivalent passage of an awake phase found that sleep selectively enhanced hippocampus-dependent memory in mice, and REM sleep, compared to NREM sleep and quiet wake, improved problem solving by assimilating new information with past experience to create a richer network for future use.
Hippocampal Contributions to Declarative Memory Consolidation During Sleep
Evidence that during sleep the reactivation of newly acquired neuronal traces has lasting implications for memory transformation and stabilization is reviewed, showing that memories can be selectively targeted and modified using learning-related stimuli.


Sleep states and memory processes in humans: procedural versus declarative memory systems.
  • C. Smith
  • Psychology, Biology
    Sleep medicine reviews
  • 2001
Preliminary results suggest that the length of the NREM-REM sleep cycle may be important for declarative memory and that stage 2 sleep may be involved with the memory for motor procedural but not cognitive procedural tasks.
Low acetylcholine during slow-wave sleep is critical for declarative memory consolidation
  • S. Gais, J. Born
  • Biology, Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2004
Increasing central nervous cholinergic activation during SWS-rich sleep by posttrial infusion of 0.75 mg of the cholinesterase inhibitor physostigmine completely blocked SWs-related consolidation of declarative memories for word pairs in human subjects, in line with predictions that a low Cholinergic tone duringSWS is essential forDeclarative memory consolidation.
Sleep-dependent memory consolidation
Converging evidence, from the molecular to the phenomenological, leaves little doubt that offline memory reprocessing during sleep is an important component of how the authors' memories are formed and ultimately shaped.
Consolidation during sleep of perceptual learning of spoken language
A role of sleep is shown in the consolidation of a naturalistic spoken-language learning task that produces generalization of phonological categories across different acoustic patterns, indicating that representations and mappings associated with generalization are refined and stabilized during sleep.
Memory reprocessing in corticocortical and hippocampocortical neuronal ensembles.
Hippocampal cells that fire together during behaviour exhibit enhanced activity correlations during subsequent sleep, with some preservation of temporal order information, and traces of recent experience are re-expressed in both hippocampal and neocortical circuits during sleep.
Reactivation of hippocampal ensemble memories during sleep.
Recordings from large ensembles of hippocampal "place cells" in three rats showed that cells that fired together when the animal occupied particular locations in the environment exhibited an increased tendency to fire together during subsequent sleep, in comparison to sleep episodes preceding the behavioral tasks.
Effects of Early and Late Nocturnal Sleep on Declarative and Procedural Memory
The experiments for the first time dissociate specific effects of early and late sleep on two principal types of memory, declarative and procedural, in humans, and the benefit from sleep on recall depended on the phase of sleep and on the type of memory.
Conjunctive representations in learning and memory: principles of cortical and hippocampal function.
This framework suggests that tasks involving rapid, incidental conjunctive learning are better tests of hippocampal function, and is implemented in a computational neural network model that can account for a wide range of data in animal learning.