Interference with the expression of a novel human polycomb protein, hPc2, results in cellular transformation and apoptosis.

@article{Satijn1997InterferenceWT,
  title={Interference with the expression of a novel human polycomb protein, hPc2, results in cellular transformation and apoptosis.},
  author={David PE Satijn and David J. Olson and Johan van der Vlag and Karien M. Hamer and Caro Lambrechts and Hans Masselink and M J Gunster and Richard G. A. B. Sewalt and Roel van Driel and Arie P. Otte},
  journal={Molecular and cellular biology},
  year={1997},
  volume={17 10},
  pages={6076-86}
}
Polycomb (Pc) is involved in the stable and heritable repression of homeotic gene activity during Drosophila development. Here, we report the identification of a novel human Pc homolog, hPc2. This gene is more closely related to a Xenopus Pc homolog, XPc, than to a previously described human Pc homolog, CBX2 (hPc1). However, the hPc2 and CBX2/hPc1 proteins colocalize in interphase nuclei of human U-2 OS osteosarcoma cells, suggesting that the proteins are part of a common protein complex. To… CONTINUE READING

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