Interference with the 19S proteasomal regulatory complex subunit PSMD4 on the sperm surface inhibits sperm-zona pellucida penetration during porcine fertilization

@article{Yi2010InterferenceWT,
  title={Interference with the 19S proteasomal regulatory complex subunit PSMD4 on the sperm surface inhibits sperm-zona pellucida penetration during porcine fertilization},
  author={Y. Yi and G. Manandhar and M. Sutovsky and S. Zimmerman and V. Jon{\'a}kov{\'a} and F. Leeuwen and R. Oko and Chang-Sik Park and P. Sutovsky},
  journal={Cell and Tissue Research},
  year={2010},
  volume={341},
  pages={325-340}
}
Proteolysis of ubiquitinated sperm and oocyte proteins by the 26S proteasome is necessary for the success of mammalian fertilization, including but not limited to acrosomal exocytosis and sperm-zona pellucida (ZP) penetration. The present study examined the role of PSMD4, an essential non-ATPase subunit of the proteasomal 19S regulatory complex responsible for proteasome-substrate recognition, in sperm-ZP penetration during porcine fertilization in vitro (IVF). Porcine sperm-ZP penetration, but… Expand
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