Interference with heparin binding and oligomerization creates a novel anti-inflammatory strategy targeting the chemokine system.

@article{Johnson2004InterferenceWH,
  title={Interference with heparin binding and oligomerization creates a novel anti-inflammatory strategy targeting the chemokine system.},
  author={Zo{\"e} Johnson and Marie H. Kosco-Vilbois and Suzanne Herren and Rocco Cirillo and Valeria Di Muzio and Paola F. Zaratin and Michela Carbonatto and Matthias Mack and Amir Smailbegovic and Mark Rose and R. F. Lever and Clive Page and Timothy N. C. Wells and Amanda E. I. Proudfoot},
  journal={Journal of immunology},
  year={2004},
  volume={173 9},
  pages={5776-85}
}
A hallmark of autoimmunity and other chronic diseases is the overexpression of chemokines resulting in a detrimental local accumulation of proinflammatory immune cells. Chemokines play a pivotal role in cellular recruitment through interactions with both cell surface receptors and glycosaminoglycans (GAGs). Anti-inflammatory strategies aimed at neutralizing the chemokine system have to-date targeted inhibition of the receptor-ligand interaction with receptor antagonists. In this study, we… CONTINUE READING

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