Interference with distinct steps of sphingolipid synthesis and signaling attenuates proliferation of U87MG glioma cells

@inproceedings{Bernhart2015InterferenceWD,
  title={Interference with distinct steps of sphingolipid synthesis and signaling attenuates proliferation of U87MG glioma cells},
  author={Eva Maria Bernhart and Sabine Damm and Andrea Wintersperger and Christoph Nusshold and Anna Martina Brunner and Ioanna Plastira and Gerald N Rechberger and Helga Reicher and C. Wadsack and Andreas Zimmer and Ernst Malle and Wolfgang Sattler},
  booktitle={Biochemical pharmacology},
  year={2015}
}
Glioblastoma is the most common malignant brain tumor, which, despite combined radio- and chemotherapy, recurs and is invariably fatal for affected patients. Members of the sphingolipid (SL) family are potent effectors of glioma cell proliferation. In particular sphingosine-1-phosphate (S1P) and the corresponding G protein-coupled S1P receptors transmit proliferative signals to glioma cells. To investigate the contribution to glioma cell proliferation we inhibited the first step of de novo SL… CONTINUE READING
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Showing 1-10 of 76 references

Ogretmen , Ceramide induced mitophagy and tumor suppression

  • B. M. Dany
  • Biochim . Biophys . Acta
  • 2015

A

  • E. L. Hedditch, B. Gao, +29 authors P. Harter
  • du Bois, I. Schwaab, E. Hogdall, S.K. Kjaer, A…
  • 2014
1 Excerpt

Molecular mechanisms of cellular cholesterol efflux

  • M. C. Phillips
  • J. Biol. Chem. 289
  • 2014
1 Excerpt

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