Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.

@article{Morgan2010InterferenceWB,
  title={Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.},
  author={Ryan E Morgan and Michael Trauner and Carlo J van Staden and Paul H. K. Lee and Bharath Ramachandran and Michael J Eschenberg and Cynthia A. Afshari and Charles W. Qualls and Ruth M Lightfoot-Dunn and Hisham Hamadeh},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2010},
  volume={118 2},
  pages={
          485-500
        }
}
The bile salt export pump (BSEP) is an efflux transporter, driving the elimination of endobiotic and xenobiotic substrates from hepatocytes into the bile. More specifically, it is responsible for the elimination of monovalent, conjugated bile salts, with little or no assistance from other apical transporters. Disruption of BSEP activity through genetic disorders is known to manifest in clinical liver injury such as progressive familial intrahepatic cholestasis type 2. Drug-induced disruption of… CONTINUE READING

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