Interference with DNA methyltransferase activity and genome methylation during F9 teratocarcinoma stem cell differentiation induced by polyamine depletion.

@article{Frostesj1997InterferenceWD,
  title={Interference with DNA methyltransferase activity and genome methylation during F9 teratocarcinoma stem cell differentiation induced by polyamine depletion.},
  author={L Frostesj{\"o} and Ingvar Holm and Birgitta Grahn and Andrea W. Page and Timothy H Bestor and Olle Heby},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 7},
  pages={4359-66}
}
When ornithine decarboxylase, the initial and highly regulated enzyme in polyamine biosynthesis, is irreversibly inactivated by alpha-difluoromethylornithine, F9 teratocarcinoma stem cells are depleted of putrescine and spermidine and as a result differentiate into a cell type which phenotypically resembles the parietal endoderm cells of the early mouse embryo. Simultaneously the level of decarboxylated S-adenosylmethionine (dcAdoMet), the aminopropyl group donor in spermidine and spermine… CONTINUE READING
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