Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome.

Abstract

The protein complex formed by the Ca2+ sensor neuronal calcium sensor 1 (NCS-1) and the guanine exchange factor protein Ric8a coregulates synapse number and probability of neurotransmitter release, emerging as a potential therapeutic target for diseases affecting synapses, such as fragile X syndrome (FXS), the most common heritable autism disorder. Using… (More)
DOI: 10.1073/pnas.1611089114

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Cite this paper

@article{Mansilla2017InterferenceOT, title={Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome.}, author={Alicia Mansilla and Antonio Chaves-Sanju{\'a}n and Nuria E Campillo and Ourania Semelidou and Loreto Mart{\'i}nez-Gonz{\'a}lez and Lourdes Infantes and Juana Mar{\'i}a Gonz{\'a}lez-Rubio and Carmen Gil and Santiago Javier Armesilla Conde and Efthimios M C Skoulakis and Alberto Ferr{\'u}s and Ana Mart{\'i}nez and Mar{\'i}a Jos{\'e} S{\'a}nchez-Barrena}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2017}, volume={114 6}, pages={E999-E1008} }