Corpus ID: 33665718

Interference of the calcium antagonists verapamil and nifedipine with lysosomal enzyme release from rabbit polymorphonuclear leukocytes.

@article{Elferink1982InterferenceOT,
  title={Interference of the calcium antagonists verapamil and nifedipine with lysosomal enzyme release from rabbit polymorphonuclear leukocytes.},
  author={J. Elferink},
  journal={Arzneimittel-Forschung},
  year={1982},
  volume={32 11},
  pages={
          1417-20
        }
}

J. Elferink

Published 1982

Medicine

Arzneimittel-Forschung

Lysosomal enzyme release by exocytosis in rabbit polymorphonuclear leukocytes, induced by chemotactic peptide ionophore A 23187 or fluoride, is inhibited by high concentrations (0.2-1 mmol/l) of the calcium antagonists verapamil and nifedipine. Inhibition of enzyme release could be reversed by increasing the extracellular Ca2+-concentration. Verapamil and nifedipine also inhibited phagocytosis of opsonized zymosan and concomitant release of lysosomal enzymes. Inhibition of phagocytosis occurred… CONTINUE READING

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