Interference of GTP hydrolysis in the mechanism of microtubule assembly: an experimental study.

@article{Carlier1984InterferenceOG,
  title={Interference of GTP hydrolysis in the mechanism of microtubule assembly: an experimental study.},
  author={Mb. Carlier and T LabsMurray Hill and Yi-der Chen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1984},
  volume={81 3},
  pages={
          771-5
        }
}
This paper reports an experimental study of the interference of GTP hydrolysis in the mechanism of microtubule assembly, following the model and theory previously published [Hill, T. L. & Carlier, M.-F. (1983) Proc. Natl. Acad. Sci. USA 80, 7234-7238]. Results from dilution experiments show that microtubules depolymerize faster below the critical concentration than expected with a reversible polymerization model. The experimental plot of flux versus tubulin concentration exhibits a slope… CONTINUE READING

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