Interference in mevalonate pathway ameliorates homocysteine-induced endothelium-dysfunction.

@article{Zhang2012InterferenceIM,
  title={Interference in mevalonate pathway ameliorates homocysteine-induced endothelium-dysfunction.},
  author={Biqi Zhang and Li-Hong Qiu and M. Fu and S. Hu},
  journal={European journal of pharmacology},
  year={2012},
  volume={692 1-3},
  pages={
          61-8
        }
}
Homocysteine is a risk factor for atherosclerosis and hypertension and induces endothelium-dysfunction. Accumulation of cholesterol and reactive oxygen species plays a key role in the endothelium-dysfunction. This study investigated the hypothesis of an involvement of mevalonate pathway and oxidative pathway in homocysteine-induced endothelial damage. Homocysteine induced impairment of the endothelium-dependent vasorelaxation of rat aortic rings by isometric tension, while it also reduced the… Expand
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