Interference by doxorubicin with DNA unwinding in MCF-7 breast tumor cells.

  title={Interference by doxorubicin with DNA unwinding in MCF-7 breast tumor cells.},
  author={Frank A. Fornari and Joyce K. Randolph and Jack C. Yalowich and M. K. Ritke and David Gewirtz},
  journal={Molecular pharmacology},
  volume={45 4},
The capacity of doxorubicin to inhibit topoisomerase II in the MCF-7 breast tumor cell line is supported by the induction of protein-associated single-strand breaks in DNA, as well as by interference with the decatenation activity of nuclear extracts. Doxorubicin also produces non-protein-associated DNA strand breaks (at a supraclinical concentration of 5 microM), which may indicate damage mediated via the generation of free radicals. However, no strand breaks are detected in DNA of MCF-7 cells… CONTINUE READING
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