Interference between Streptococcus pneumoniae and Staphylococcus aureus: In vitro hydrogen peroxide-mediated killing by Streptococcus pneumoniae.

@article{RegevYochay2006InterferenceBS,
  title={Interference between Streptococcus pneumoniae and Staphylococcus aureus: In vitro hydrogen peroxide-mediated killing by Streptococcus pneumoniae.},
  author={Gili Regev-Yochay and Krzysztof Trzciński and Claudette M. Thompson and Richard Malley and Marc Lipsitch},
  journal={Journal of bacteriology},
  year={2006},
  volume={188 13},
  pages={4996-5001}
}
The bactericidal activity of Streptococcus pneumoniae toward Staphylococcus aureus is mediated by hydrogen peroxide. Catalase eliminated this activity. Pneumococci grown anaerobically or genetically lacking pyruvate oxidase (SpxB) were not bactericidal, nor were nonpneumococcal streptococci. These results provide a possible mechanistic explanation for the interspecies interference observed in epidemiologic studies. 
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