Interference among deleterious mutations favours sex and recombination in finite populations

@article{Keightley2006InterferenceAD,
  title={Interference among deleterious mutations favours sex and recombination in finite populations},
  author={Peter D. Keightley and Sarah Perin Otto},
  journal={Nature},
  year={2006},
  volume={443},
  pages={89-92}
}
Sex and recombination are widespread, but explaining these phenomena has been one of the most difficult problems in evolutionary biology. Recombination is advantageous when different individuals in a population carry different advantageous alleles. By bringing together advantageous alleles onto the same chromosome, recombination speeds up the process of adaptation and opposes the fixation of harmful mutations by means of Muller's ratchet. Nevertheless, adaptive substitutions favour sex and… Expand
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TLDR
Analytical two- and three-locus models are developed to study the effect of recurrent deleterious mutations on a modifier gene increasing sex, in a finite diploid population and show that excess of heterozygosity generated by finite population size is an important component of selection for sex. Expand
Influences of Dominance and Evolution of Sex in Finite Diploid Populations
TLDR
An infinite loci model is adopted and shows that with different levels of dominance, segregation and recombination may play different roles, and illustrates that the existence of dominance is an important mechanism that affects the evolution of sex. Expand
Evolution of sex and recombination in large, finite populations
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Computer simulations are used to investigate the evolution of a recombination modifier under three different scenarios of recurrent mutation in a finite population and observe that adding even a small number of advantageous mutations increases the fixation rate of modifiers that increase recombination, especially if the effects of deleterious mutations are weak. Expand
Genetic linkage and natural selection
  • N. Barton
  • Medicine, Biology
  • Philosophical Transactions of the Royal Society B: Biological Sciences
  • 2010
TLDR
It is plausible that spatial and temporal fluctuations in selection generate much more fitness variance, and hence selection for recombination, than can be explained by uniformly deleterious mutations or species-wide selective sweeps. Expand
Relative effects of segregation and recombination on the evolution of sex in finite diploid populations
TLDR
It was observed that the twofold cost of sex was easily to overcome in diploids if a sex modifier caused a moderate frequency of sex, and the combined effects of segregation and recombination strongly contributed to the evolution of sex in diPloids. Expand
Sex and Deleterious Mutations
TLDR
The quantification of the range of selective effects that favors recombination leads to suggest that, if in stressful environments the effect of deleterious mutations is enhanced, a connection between sex and stress could be expected, as it is found in several species. Expand
Sex and recombination purge the genome of deleterious alleles: An Individual Based Modeling Approach
TLDR
The purifying selection hypothesis, the hypothesis that recombination due to sexual reproduction helps to eliminate deleterious alleles from the genome through the selection of reduced function mutations, is corroborated. Expand
Genetic Load in Sexual and Asexual Diploids: Segregation, Dominance and Genetic Drift
TLDR
Overall, the mutation load that arises through the absence of segregation in asexuals may greatly exceed previous predictions that ignored genetic drift. Expand
Selection for sex in finite populations
  • D. Roze
  • Biology, Medicine
  • Journal of evolutionary biology
  • 2014
TLDR
Extrapolating the results from three‐locus models to a large number of loci at mutation–selection balance indicates that in the parameter range where indirect selection is strong enough to outweigh a substantial cost of sex, interactions between selected loci have a stronger effect than the sum of individual effects of each selected locus. Expand
Recombination Speeds Adaptation by Reducing Competition between Beneficial Mutations in Populations of Escherichia coli
TLDR
Using the F plasmid to mediate recombination in the bacterium Escherichia coli and measuring its effect on adaptation at high and low mutation rates provides experimental support for the Fisher–Muller model and demonstrates that plasmids-mediated gene transfer can accelerate bacterial adaptation. Expand
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