Interference among deleterious mutations favours sex and recombination in finite populations

@article{Keightley2006InterferenceAD,
  title={Interference among deleterious mutations favours sex and recombination in finite populations},
  author={P. Keightley and S. Otto},
  journal={Nature},
  year={2006},
  volume={443},
  pages={89-92}
}
  • P. Keightley, S. Otto
  • Published 2006
  • Biology, Medicine
  • Nature
  • Sex and recombination are widespread, but explaining these phenomena has been one of the most difficult problems in evolutionary biology. Recombination is advantageous when different individuals in a population carry different advantageous alleles. By bringing together advantageous alleles onto the same chromosome, recombination speeds up the process of adaptation and opposes the fixation of harmful mutations by means of Muller's ratchet. Nevertheless, adaptive substitutions favour sex and… CONTINUE READING
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    References

    SHOWING 1-10 OF 36 REFERENCES
    SELECTION FOR RECOMBINATION IN SMALL POPULATIONS
    • S. Otto, N. Barton
    • Biology, Medicine
    • Evolution; international journal of organic evolution
    • 2001
    • 230
    • PDF
    Selection on a modifier of recombination rate due to linked deleterious mutations.
    • S. Pálsson
    • Biology, Medicine
    • The Journal of heredity
    • 2002
    • 11
    Mutation-selection balance and the evolutionary advantage of sex and recombination.
    • 378
    • PDF
    The evolutionary advantage of recombination.
    • 1,342
    • PDF
    Evolution of Recombination Due to Random Drift
    • 172
    • PDF
    Selection for Recombination in Structured Populations
    • 100
    • PDF
    Deleterious mutations as an evolutionary factor. 1. The advantage of recombination.
    • 174