Interference-Free Proteome Quantification with MS/MS-based Isobaric Isotopologue Detection

@inproceedings{Bamberger2014InterferenceFreePQ,
  title={Interference-Free Proteome
Quantification with MS/MS-based
Isobaric Isotopologue Detection},
  author={Casimir Bamberger and Sandra Pankow and Sung Kyu Robin Park and John R. Yates},
  booktitle={Journal of proteome research},
  year={2014}
}
Chemical labeling of peptides prior to shotgun proteomics allows relative quantification of proteins in biological samples independent of sample origin. Current strategies utilize isobaric labels that fragment into reporter ions. However, quantification of reporter ions results in distorted ratio measurements due to contaminating peptides that are co… CONTINUE READING