Interfacial water molecules in SH3 interactions: Getting the full picture on polyproline recognition by protein-protein interaction domains.

@article{ZafraRuano2012InterfacialWM,
  title={Interfacial water molecules in SH3 interactions: Getting the full picture on polyproline recognition by protein-protein interaction domains.},
  author={Ana Zafra-Ruano and Irene Luque},
  journal={FEBS letters},
  year={2012},
  volume={586 17},
  pages={2619-30}
}
The recognition of proline-rich sequences by protein-protein interaction modules is essential for many cellular processes. Nonetheless, in spite of the wealth of structural and functional information collected over the last two decades, polyproline recognition is still not well understood. The patent inconsistency between the generally accepted description of SH3 interactions, based primarily on the stacking of hydrophobic surfaces, and their markedly exothermic character is a clear… CONTINUE READING

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