Interfacial inhibitors: targeting macromolecular complexes

@article{Pommier2011InterfacialIT,
  title={Interfacial inhibitors: targeting macromolecular complexes},
  author={Yves Pommier and Cyril Marchand},
  journal={Nature Reviews Drug Discovery},
  year={2011},
  volume={11},
  pages={25-36}
}
Interfacial inhibitors belong to a broad class of natural products and synthetic drugs that are commonly used to treat cancers as well as bacterial and HIV infections. They bind selectively to interfaces as macromolecular machines assemble and are set in motion. The bound drugs transiently arrest the targeted molecular machines, which can initiate allosteric effects, or desynchronize macromolecular machines that normally function in concert. Here, we review five archetypical examples of… CONTINUE READING
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