Interface between tauopathies and synucleinopathies: A tale of two proteins

  title={Interface between tauopathies and synucleinopathies: A tale of two proteins},
  author={W. Galpern and A. Lang},
  journal={Annals of Neurology},
  • W. Galpern, A. Lang
  • Published 2006
  • Biology, Medicine
  • Annals of Neurology
  • Neurodegenerative diseases are often classified based on the abnormal accumulation of synuclein or tau. Traditionally, these disorders have been viewed as distinct clinical and pathological entities. However, advances in molecular genetics and protein biochemistry have shown intriguing overlaps. The most common synucleinopathy, Parkinson's disease, is characterized by extrapyramidal motor dysfunction, whereas the most common tauopathy, Alzheimer's disease, is defined by dementia. Yet there is… CONTINUE READING
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