Interface between tauopathies and synucleinopathies: A tale of two proteins

@article{Galpern2006InterfaceBT,
  title={Interface between tauopathies and synucleinopathies: A tale of two proteins},
  author={W. Galpern and A. Lang},
  journal={Annals of Neurology},
  year={2006},
  volume={59}
}
  • W. Galpern, A. Lang
  • Published 2006
  • Biology, Medicine
  • Annals of Neurology
  • Neurodegenerative diseases are often classified based on the abnormal accumulation of synuclein or tau. Traditionally, these disorders have been viewed as distinct clinical and pathological entities. However, advances in molecular genetics and protein biochemistry have shown intriguing overlaps. The most common synucleinopathy, Parkinson's disease, is characterized by extrapyramidal motor dysfunction, whereas the most common tauopathy, Alzheimer's disease, is defined by dementia. Yet there is… CONTINUE READING
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    References

    SHOWING 1-10 OF 158 REFERENCES
    More than just two peas in a pod: common amyloidogenic properties of tau and α-synuclein in neurodegenerative diseases
    • 166
    alpha-Synuclein is phosphorylated in synucleinopathy lesions.
    • 658
    α-Synuclein is phosphorylated in synucleinopathy lesions
    • 1,253
    Tau and alpha-synuclein pathology in amygdala of Parkinsonism-dementia complex patients of Guam.
    • 54
    The new mutation, E46K, of α‐synuclein causes parkinson and Lewy body dementia
    • 2,327
    • Highly Influential
    Lewy body-related α-synucleinopathy in the aged human brain
    • 217
    Lewy body-related alpha-synucleinopathy in the aged human brain.
    • 138
    • Highly Influential
    Phosphorylated alpha-synuclein is ubiquitinated in alpha-synucleinopathy lesions.
    • 168