Interface analysis of small GTP binding protein complexes suggests preferred membrane orientations.

@article{Vetter2017InterfaceAO,
  title={Interface analysis of small GTP binding protein complexes suggests preferred membrane orientations.},
  author={Ingrid R. Vetter},
  journal={Biological chemistry},
  year={2017},
  volume={398 5-6},
  pages={637-651}
}
Crystal structures of small GTP binding protein complexes with their effectors and regulators reveal that one particularly flat side of the G domain that contains helix α4 and the C-terminal helix α5 is practically devoid of contacts. Although this observation seems trivial as the main binding targets are the switch I and II regions opposite of this side, the fact that all interacting proteins, even the largest ones, seem to avoid occupying this area (except for Ran, that does not localize to… CONTINUE READING