Interethnic variation in the metabolic inactivation of digoxin by the gut flora.

@article{Alam1988InterethnicVI,
  title={Interethnic variation in the metabolic inactivation of digoxin by the gut flora.},
  author={Ahmed Nawsher Alam and Jayat Saha and Jay F Dobkin and John Lindenbaum},
  journal={Gastroenterology},
  year={1988},
  volume={95 1},
  pages={117-23}
}
Digoxin is metabolized to cardioinactive reduced metabolites (digoxin reduction products) in some patients by anaerobic bacteria present in the gut flora. We compared the tendencies of Americans and Bangladeshis to reduce digoxin by this pathway. Of 97 normal Americans in New York City, 34 (35.1%) were metabolizers in contrast to 14 of 100 Bangladeshis in Dhaka (p less than 0.002). Forty-three (35.8%) of 120 American patients in New York City receiving digoxin reduced the drug compared with 4… CONTINUE READING