Interethnic Differences in Drug Response: The Contribution of Genetic Variability in β Adrenergic Receptor and Cytochrome P4502C9

@article{Muszkat2007InterethnicDI,
  title={Interethnic Differences in Drug Response: The Contribution of Genetic Variability in $\beta$ Adrenergic Receptor and Cytochrome P4502C9},
  author={Mordechai Muszkat},
  journal={Clinical Pharmacology \& Therapeutics},
  year={2007},
  volume={82}
}
  • M. Muszkat
  • Published 1 August 2007
  • Biology
  • Clinical Pharmacology & Therapeutics
Ethnic differences in drug response have been extensively reported, and ethnicity has been suggested to be useful clinically as a predictor of drug response. Genetic polymorphisms in the genes encoding β1 adrenergic receptor (AR) and β2 AR, targets of β AR antagonists, and in cytochrome P4502C9, the enzyme involved in warfarin metabolism, have the potential to explain some of the observed ethnic variability in drug response and to improve clinical practice. 
Ethnicity and Response to Drug Therapy
TLDR
In‐depth information of the impact of ethnicity on these relationships has the huge potential of achieving optimal quality use of drugs as well as improving the efficacy and safety of antilipidemic drugs.
Impact of the β-1 adrenergic receptor polymorphism on tolerability and efficacy of bisoprolol therapy in Korean heart failure patients: association between β adrenergic receptor polymorphism and bisoprolol therapy in heart failure (ABBA) study
TLDR
The ADRB1 Gly389X genotype showed greater response to bisoprolol than the Arg389Arg genotype, suggesting the potential of individually tailoring β-blocker therapy according to genotype.
Race, ethnicity, ancestry, and pharmacogenetics.
  • T. Urban
  • Biology, Medicine
    The Mount Sinai journal of medicine, New York
  • 2010
TLDR
The relationship between the concepts of race, ethnicity, and ancestry and how these concepts have been applied to pharmacogenetics are described and examples of the benefits and pitfalls associated with the use of racial or ethnic labels in genetic studies are provided.
Pharmacogenetics of nicotine addiction: role of dopamine.
The neurotransmitter dopamine (DA) plays a central role in addictive disorders, including nicotine addiction. Specific DA-related gene variants have been studied to identify responsiveness to
Pharmacogenetics and obstetric anesthesia.
  • R. Landau
  • Medicine, Biology
    Anesthesiology clinics
  • 2008
Pathophysiology of allergic drug reactions.
TLDR
Physicians should always insist on obtaining a thorough patient's history regarding drug allergy as well as on ascertaining details regarding the medication used, its route of administration, dosage and the treatment duration in order to properly assess risk of drug allergies and suggest further work-up in that regard.
Current Japanese regulatory situations of pharmacogenomics in drug administration
TLDR
The current situations and projects in regulatory implementations of PGx in drug administrations in Japan are summarized, including activities to promote PGx-based drug/device developments and therapies and the future tasks for utilization in drug evaluations and clinical practices are discussed.
Post-exercise hypotension: possible relationship with ethnic and genetic factors Hipotensão pós-exercício: possível relação com fatores étnicos e genéticos
TLDR
The environmental and, mainly, ethnic and genetic factors related to PEH are reviewed and it seems that the greatest decline in PA occurs mainly after low-intensity aerobic exercise performed by normotensive or borderline hypertensive adult men.
Practical recommendations for the use of beta-blockers in chronic obstructive pulmonary disease
TLDR
Beta-blockers should not be used to treat COPD patients who do not have conditions with clear guideline-directed recommendations for their use, and Vigilance is recommended in prescribing these medications for indications where another drug class could be utilized.
Predictors of plasma polychlorinated biphenyl concentrations among reproductive-aged black women.
...
...

References

SHOWING 1-10 OF 38 REFERENCES
Clinical Consequences of Cytochrome P450 2C9 Polymorphisms
β1‐Adrenergic Receptor Polymorphisms and Antihypertensive Response to Metoprolol
Ethnic Differences in Drug Disposition and Responsiveness
TLDR
The evidence for ethnic differences in drug disposition and sensitivity is reviewed and should encourage further investigations to elucidate the extent of such differences, their causes and their therapeutic impact.
Population differences in S‐warfarin metabolism between CYP2C9 genotype‐matched Caucasian and Japanese patients
TLDR
Using the unbound oral clearance of S‐warfarin as an in vivo phenotypic trait measure for cytochrome P450 metabolic activity differences between genotypically matched Caucasian and Japanese patients is investigated.
Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose.
TLDR
VKORC1 haplotypes can be used to stratify patients into low-, intermediate-, and high-dose warfarin groups and may explain differences in dose requirements among patients of different ancestries.
Pharmacology and physiology of human adrenergic receptor polymorphisms.
TLDR
The consequences of common genetic polymorphisms in adrenergic receptor subtypes are reviewed in terms of signaling, human physiology and disease, and response to therapy.
...
...