Interethnic Differences in Drug Response: The Contribution of Genetic Variability in β Adrenergic Receptor and Cytochrome P4502C9

  title={Interethnic Differences in Drug Response: The Contribution of Genetic Variability in $\beta$ Adrenergic Receptor and Cytochrome P4502C9},
  author={Mordechai Muszkat},
  journal={Clinical Pharmacology \& Therapeutics},
  • M. Muszkat
  • Published 1 August 2007
  • Biology
  • Clinical Pharmacology & Therapeutics
Ethnic differences in drug response have been extensively reported, and ethnicity has been suggested to be useful clinically as a predictor of drug response. Genetic polymorphisms in the genes encoding β1 adrenergic receptor (AR) and β2 AR, targets of β AR antagonists, and in cytochrome P4502C9, the enzyme involved in warfarin metabolism, have the potential to explain some of the observed ethnic variability in drug response and to improve clinical practice. 
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Clinical Consequences of Cytochrome P450 2C9 Polymorphisms
β1‐Adrenergic Receptor Polymorphisms and Antihypertensive Response to Metoprolol
Ethnic Differences in Drug Disposition and Responsiveness
The evidence for ethnic differences in drug disposition and sensitivity is reviewed and should encourage further investigations to elucidate the extent of such differences, their causes and their therapeutic impact.
Population differences in S‐warfarin metabolism between CYP2C9 genotype‐matched Caucasian and Japanese patients
Using the unbound oral clearance of S‐warfarin as an in vivo phenotypic trait measure for cytochrome P450 metabolic activity differences between genotypically matched Caucasian and Japanese patients is investigated.
Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose.
VKORC1 haplotypes can be used to stratify patients into low-, intermediate-, and high-dose warfarin groups and may explain differences in dose requirements among patients of different ancestries.
Pharmacology and physiology of human adrenergic receptor polymorphisms.
The consequences of common genetic polymorphisms in adrenergic receptor subtypes are reviewed in terms of signaling, human physiology and disease, and response to therapy.