Research on disruptive innovation is characterized by a scattered and conflicting nature. This paper suggests a new approach to raising important and interdependent research questions, theory integration, and methods across challenges and disciplines. The contribution is limited to the digital domain through the research question: What are research challenges in digital disruption research, and how do we frame them? Seven interdisciplinary research challenges and ten research perspectives are identified and crosstabulated in an interdisciplinary digital disruption research framework. The framework is the contribution of the paper, and it is tested on an interdisciplinary workshop through a process of researchers working together in different interdisciplinary constellations. In conclusion, the research framework can be used as intended, but tests including a concrete case and industrial innovation managers are needed.