Interdigital webbing retention in bat wings illustrates genetic changes underlying amniote limb diversification.

@article{Weatherbee2006InterdigitalWR,
  title={Interdigital webbing retention in bat wings illustrates genetic changes underlying amniote limb diversification.},
  author={Scott D Weatherbee and Richard R. Behringer and John J. Rasweiler and Lee Niswander},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 41},
  pages={15103-7}
}
Developmentally regulated programmed cell death sculpts the limbs and other embryonic organs in vertebrates. One intriguing example of species-specific differences in apoptotic extent is observed in the tissue between the digits. In chicks and mice, bone morphogenetic proteins (Bmps) trigger apoptosis of the interdigital mesenchyme, leading to freed digits, whereas in ducks, Bmp antagonists inhibit the apoptotic program, resulting in webbed feet. Here, we show that the phyllostomid bat Carollia… CONTINUE READING
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