Interdependent regulation of intracellular acidification and SHP-1 in apoptosis.

@article{Thangaraju1999InterdependentRO,
  title={Interdependent regulation of intracellular acidification and SHP-1 in apoptosis.},
  author={Muthusamy Thangaraju and Kirti Sharma and David N. Liu and S. H. Shen and Coimbatore B. Srikant},
  journal={Cancer research},
  year={1999},
  volume={59 7},
  pages={1649-54}
}
The G protein-coupled receptor agonist somatostatin (SST)-induces apoptosis in MCF-7 human breast cancer cells. This is associated with induction of wild-type p53, Bax, and an acidic endonuclease. We have shown recently that its cytotoxic signaling is mediated via membrane-associated SHP-1 and is dependent on decrease in intracellular pH (pHi) to 6.5. Here we investigated the relationship between intracellular acidification and SHP-1 in cytotoxic signaling. Clamping of pHi at 7.25 by the proton… CONTINUE READING