Interdependent Regulation of Intracellular Acidification and SHP-1 in Apoptosis 1

Abstract

The G protein-coupled receptor agonist somatostatin (SST)-induces apoptosis in MCF-7 human breast cancer cells. This is associated with induction of wild-type p53, Bax, and an acidic endonuclease. We have shown recently that its cytotoxic signaling is mediated via membraneassociated SHP-1 and is dependent on decrease in intracellular pH (pHi) to 6.5. Here… (More)

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