Interdependency of protein-release completeness and polymer degradation in PLGA-based implants.

@article{Ghalanbor2013InterdependencyOP,
  title={Interdependency of protein-release completeness and polymer degradation in PLGA-based implants.},
  author={Zahra Ghalanbor and M. D. S. A. Koerber and Roland A Bodmeier},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2013},
  volume={85 3 Pt A},
  pages={624-30}
}
Release of BSA (model protein) from hot-melt extruded poly(lactide-co-glycolide) (PLGA)-based implants was incomplete. A residual mass of covalent BSA-PLGA adducts was still present after 6 months. The objective of this study was to increase the completeness of BSA release. BSA reduced the PLGA degradation and erosion rate as well as the extent of erosion. An increased uptake of release medium in the presence of BSA in addition to the early outflux of PLGA oligomers resulted in a reduction of… CONTINUE READING