Interdependence of signal processing and analysis of urine 1H NMR spectra for metabolic profiling.

@article{Zhang2009InterdependenceOS,
  title={Interdependence of signal processing and analysis of urine 1H NMR spectra for metabolic profiling.},
  author={Shucha Zhang and Cheng Zheng and Ian R. Lanza and K. Sreekumaran Nair and Daniel Raftery and Olga Vitek},
  journal={Analytical chemistry},
  year={2009},
  volume={81 15},
  pages={6080-8}
}
Metabolic profiling of urine presents challenges because of the extensive random variation of metabolite concentrations and the dilution resulting from changes in the overall urine volume. Thus statistical analysis methods play a particularly important role; however, appropriate choices of these methods are not straightforward. Here we investigate constant and variance-stabilization normalization of raw and peak picked spectra, for use with exploratory analysis (principal component analysis… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

Similar Papers

Loading similar papers…