Interdependence of PRC1 and PRC2 for recruitment to Polycomb Response Elements

@inproceedings{Kahn2016InterdependenceOP,
  title={Interdependence of PRC1 and PRC2 for recruitment to Polycomb Response Elements},
  author={Tatyana G. Kahn and Eshagh Dorafshan and Dorothea Schultheis and Aman Zare and Per Stenberg and Ingolf Reim and Vincenzo Pirrotta and Yuri B. Schwartz},
  booktitle={Nucleic acids research},
  year={2016}
}
Polycomb Group (PcG) proteins are epigenetic repressors essential for control of development and cell differentiation. They form multiple complexes of which PRC1 and PRC2 are evolutionary conserved and obligatory for repression. The targeting of PRC1 and PRC2 is poorly understood and was proposed to be hierarchical and involve tri-methylation of histone H3 (H3K27me3) and/or monoubiquitylation of histone H2A (H2AK118ub). Here, we present a strict test of this hypothesis using the Drosophila… CONTINUE READING
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