Interconversion of phospho- and dephospho- forms of pig heart pyruvate dehydrogenase.

@article{Wieland1970InterconversionOP,
  title={Interconversion of phospho- and dephospho- forms of pig heart pyruvate dehydrogenase.},
  author={O. H. Wieland and Elmar A Siess},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1970},
  volume={65 4},
  pages={947-54}
}
Pyruvate dehydrogenase from pig heart exists in active and inactive forms. Interconversion from the active (dephospho) form into the inactive (phospho) form is catalyzed by an ATP-dependent kinase. Conversely the enzyme is reactivated by a phosphatase which removes the phosphate group from the protein. By gradient centrifugation pyruvate dehydrogenase was… CONTINUE READING