Interconversion of different molecular weight forms of the orotate phosphoribosyltransferase.orotidine-5'-phosphate decarboxylase enzyme complex from mouse Ehrlich ascites cells.


Complex U consists of orotate phosphoribosyltransferase (EC and orotidineG’-phosphate decarboxylase (EC, the last two enzymes of the de nova pathway for UMP biosynthesis. Earlier studies had shown that orotate and magnesium 5-phosphoribosyl-1-pyrophosphate, substrates for the transferase, and orotidine 5’-monophosphate (OMP), the product… (More)


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