Interconversion of cortisol and cortisone in the baboon placenta at midgestation: expression of 11beta-hydroxysteroid dehydrogenase type 1 messenger RNA.

@article{Pepe1996InterconversionOC,
  title={Interconversion of cortisol and cortisone in the baboon placenta at midgestation: expression of 11beta-hydroxysteroid dehydrogenase type 1 messenger RNA.},
  author={Gerald J. Pepe and Brendan J. Waddell and Marcia G. Burch and Eugene D. Albrecht},
  journal={The Journal of steroid biochemistry and molecular biology},
  year={1996},
  volume={58 4},
  pages={403-10}
}
At midgestation in the baboon, 11beta-hydroxysteroid dehydrogenase (11beta-HSD) catalysed interconversion of cortisol (F) and cortisone (E) during transuterine passage favors the formation of F. Because the site(s) of oxidation/reduction of F and E are not clear, the present study compared F-E interconversion in placenta, decidua and chorion in vitro. In addition, because the reduction of E to F is catalysed only by the 11beta-HSD-1, we also determined whether the mRNA for this enzyme was… CONTINUE READING