Interchangeable modules in bacterial thiol-disulfide exchange pathways.

  title={Interchangeable modules in bacterial thiol-disulfide exchange pathways.},
  author={Thijs R. H. M. Kouwen and Jan Maarten van Dijl},
  journal={Trends in microbiology},
  volume={17 1},
Thiol-disulfide oxidoreductases (TDORs) catalyze thiol-disulfide exchange reactions that are crucial for protein activity and stability. Specifically, they can function as thiol oxidases, disulfide reductases or disulfide isomerases. The generally established view is that particular TDORs act unidirectionally within a fixed cascade of specific, sequentially arranged reactions. However, recent studies on both Gram-negative and Gram-positive bacteria imply that this view needs to be expanded, at… CONTINUE READING