Interchangeability and predictive performance of empirical tolerance models.

  title={Interchangeability and predictive performance of empirical tolerance models.},
  author={Marie G{\aa}rdmark and L Brynne and Margareta Hammarlund-Udenaes and Mats O. Karlsson},
  journal={Clinical pharmacokinetics},
  volume={36 2},
Models of tolerance are commonly derived on empirical grounds, because of lack of knowledge about the mechanism of tolerance or because of the difficulty of appropriately simplifying complex physiological processes. The present study was performed to evaluate the interchangeability of tolerance models used in the literature and to address some determinants for selection of an appropriate design and data analysis strategy. Seven models were chosen (noncompetitive antagonist model, partial… CONTINUE READING
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